向阳飞, PhD助理教授研究员博士生导师

电话：

邮箱： xiangyf@@shanghaitech.edu.cn

传真：

地址：上海市浦东新区华夏中路393号

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中文信息English

干细胞与神经生物学研究组

课题组长

姓名：

向阳飞助理教授研究员博士生导师, PhD, 助理教授

职务：

所在院所：

新葡8883官网AMG官网

荣誉称号：

教育经历：

2002/09—2006/06，怀化学院，学士
2006/09—2009/06，暨南大学，硕士
2009/09—2013/06，暨南大学，博士

博士后及工作经历：

2013/08—2019/05，耶鲁大学，博士后
2019/05—2020/02，耶鲁大学，副研究员
2020/03—至今，上海科技大学，新葡8883官网AMG官网，助理教授 (TENURE-TRACK)

课题组简介

研究方向：

干细胞与神经类器官

研究内容：

1）神经类器官技术开发；

2）基于类器官技术的发育与疾病研究。

课题组网站：www.yxlab.org

欢迎生物背景、或生信背景的新成员加入我们课题组！

课题组网站：

研究成果展示

实验室聚焦神经类器官原创技术开发与应用探索：

1）多组织互作疾病模拟新技术：基于共发育构建多组织复合类器官，建立自组织、共发育的神经、肌肉、骨骼三组织复合类器官模型（Cell Stem Cell 2025）。

2）脑精细结构体外模拟技术：建立脊髓三叉神经核特异的脑类器官，建立脑核团相关的多脑区复合，体外研究核团与靶区域的轴突连接（Cell Stem Cell 2024）。

3）脑精细结构体外模拟技术：建立具备核团特征的腹侧丘脑类器官，研究人脑核团特异的发育异常（Cell Stem Cell 2023）。

4）脑发育疾病机制及干预：利用干细胞体外分化、脑类器官等，研究神经发育疾病Rett Syndrome机制与药物靶点（Molecular Cell 2020）。

5）实验室受国际关注：课题组采访介绍（Cell Stem Cell 2020）。

6）实验室受国际关注：课题组采访介绍（Cell Stem Cell 2021）。

7）脑类器官血管化新技术：基于细胞编程实现多谱系复合类器官构建，建立脑类器官血管化复合（Nature Methods 2019）。

8）复合脑类器官探索环路发育：建立丘脑类器官；构建多脑区复合类器官，模拟丘脑与皮层间轴突投射连接（Cell Stem Cell 2019）。

9）复合脑类器官探索神经元迁移：建立皮质、腹侧端脑类器官；构建多脑区复合类器官，模拟人类中间神经元迁移（Cell Stem Cell 2017）。

开设课程：1）再生医学原理（本科生、研究生）

2）类脑器官（本科生）

参与课程：1）生物医学工程基础

2）实验生物学

代表性论文（*第一作者，#通讯作者）

1. Liu Y, Zhu J, Lu X, Zhuang X, Wei J, Jiang L, Zhou W, Pang W, Yin Y, Chen Z, Cao Y, Zhang Q, Chen S, Chu S, Zhang X, Xiang Y.Human PSC-derived organoids model sympathetic ganglion development and its functional crosstalk with the heart.Cell Stem Cell. Dec 2025. doi: 10.1016/j.stem.2025.11.003..
2. Pang W, Xiang Y..Unlocking human brain networks by assembling circuits in vitro and in vivo.Cell Stem Cell. Dec 2025. 32(12):1795-1797..
3. Chen S, Xiang Y.Brain assembloids decode human cortical networks in Rett syndrome.Cell Rep. Dec 2025. 44(12):116709..
4. Yin Y*, Zhou W*, Zhu J*, Chen Z, Jiang L, Zhuang X, Chen J, Wei J, Lu X, Liu Y, Pang W, Zhang Q, Cao Y, Li Z, Zhu Y, Xiang Y^#.Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells.Cell Stem Cell. 2025 Jan 2. 32(1):157-171.
5. Wei Pang*, Jinkui Zhu*, Kexin Yang, Xiaona Zhu, Wei Zhou, Linlin Jiang , Xuran Zhuang, Yantong Liu , Jianfeng Wei, Xiaoxiang Lu, Yao Yin, Ziling Chen, Yangfei Xiang^#.Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei.Cell Stem Cell. Aug 28 2024. S1934-5909(24)00290-X.
6. Kiral FR*, Cakir B, Tanaka Y, Kim J, Yang WS, Wehbe F, Kang YJ, Zhong M, Sancer G, Lee SH, Xiang Y^#, Park IH^#.Generation of ventralized human thalamic organoids with thalamic reticular nucleus.Cell Stem Cell. 2023 Mar 28. 30(5):677-688.e5. DOI: 10.1016/j.stem.2023.03.007.
7. Xiang Y^#*, Park IH^#..Brain organoids: from unguided to regionalized to nucleus-specific.Life Medicine. Mar 2024. ;3(2):lnae014.
8. Barral, Serena*; Xiang, Yangfei; Birey, Fikri.Improving in vitro modeling of human brain with future brain organoids.FRONTIERS IN MOLECULAR NEUROSCIENCE. 09 Aug 2022. 15.
9. Lu, Xiaoxiang*; Yang, Jiajie; Xiang, Yangfei.Modeling human neurodevelopmental diseases with brain organoids.CELL REGENERATION. Jan 2022. 11(1).
10. Xiang, Yangfei*.Human brain organoids: development and application.CANCER SCIENCE. 01 Feb 2022. 113:806-806.
11. Tikhonova A^#*^#*^#, Xiang Y^#*^#, Gifford C^#*^#.Early-career researchers in the time of COVID-19: Starting a new lab during a pandemic.Cell Stem Cell. May 2021. 28(5):808-810.
12. Yoshiaki Tanaka*; Bilal Cakir; Yangfei Xiang; Gareth J. Sullivan; In-Hyun Park.Synthetic Analyses of Single-Cell Transcriptomes From Multiple Brain Organoids and Fetal Brain.CELL REPORTS. 2020. 30(6):1682-1689.
13. Smith, Quinton*; McKinley, Kara L.*; Chan, Chii Jou*; Sikandar, Shaheen*; Xiang, Yangfei*; Passaro, Diana*.Introductions to the Community: Early-Career Researchers in the Time of COVID-19.CELL STEM CELL. 05 Nov 2020. 27(5):702-704.
14. Lim, Yolpanhchana*; Beane-Ebel, Jennifer E.; Tanaka, Yoshiaki; Ning, Boting; Husted, Christopher R.; Henderson, David C.; Xiang, Yangfei; Park, In-Hyun; Farrer, Lindsay A.; Zhang, Huiping.Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.TRANSLATIONAL PSYCHIATRY. 02 Oct 2021. 11(1).
15. Xiang, Yangfei*; Tanaka, Yoshiaki*; Patterson, Benjamin; Hwang, Sung-Min; Hysolli, Eriona; Cakir, Bilal; Kim, Kun-Yong; Wang, Wanshan; Kang, Young-Jin; Clement, Ethan M.; Zhong, Mei; Lee, Sang-Hun; Cho, Yee Sook; Patra, Prabir; Sullivan, Gareth J.; Weissman, Sherman M.; Park, In-Hyun.Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.MOLECULAR CELL. 2020. 79(1):84-+.
16. Xiang, Yangfei*; Cakir, Bilal; Park, In-Hyun.Deconstructing and reconstructing the human brain with regionally specified brain organoids.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. Mar 2021. 111:40-51.
17. Cakir, Bilal*; Xiang, Yangfei*; Tanaka, Yoshiaki; Kural, Mehmet H.; Parent, Maxime; Kang, Young-Jin; Chapeton, Kayley; Patterson, Benjamin; Yuan, Yifan; He, Chang-Shun; Raredon, Micha Sam B.; Dengelegi, Jake; Kim, Kun-Yong; Sun, Pingnan; Zhong, Mei; Lee, Sangho; Patra, Prabir; Hyder, Fahmeed; Niklason, Laura E.; Lee, Sang-Hun; Yoon, Young-Sup; Park, In-Hyun.Engineering of human brain organoids with a functional vascular-like system.NATURE METHODS. 2019. 16(11):1169.
18. Xiang, Yangfei*; Bilal Cakir; In-Hyun Park.Generation of regionally specified human brain organoids resembling thalamus development.CELL PRESS: STAR PROTOCOLS. 2019.
19. Xiang, Yangfei*; Tanaka, Yoshiaki*; Cakir, Bilal; Patterson, Benjamin; Kim, Kun-Yong; Sun, Pingnan; Kang, Young-Jin; Zhong, Mei; Liu, Xinran; Patra, Prabir; Lee, Sang-Hun; Weissman, Sherman M.; Park, In-Hyun.hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.CELL STEM CELL. 2019. 24(3):487.
20. Xiang, Yangfei*; Tanaka Yoshiaki; Benjamin Patterson; Bilal Cakir; Kun-Yong Kim; Yee Sook Cho; In-Hyun Park.Generation and fusion of human cortical and medial ganglionic eminence brain organoids.CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2018.
21. Kim, Kun-Yong*; Tanaka, Yoshiaki; Su, Juan; Cakir, Bilal; Xiang, Yangfei; Patterson, Benjamin; Ding, Junjun; Jung, Yong-Wook; Kim, Ji-Hyun; Hysolli, Eriona; Lee, Haelim; Dajani, Rana; Kim, Jonghwan; Zhong, Mei; Lee, Jeong-Heon; Skalnik, David; Lim, Jeong Mook; Sullivan, Gareth J.; Wang, Jianlong; Park, In-Hyun.Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.NATURE COMMUNICATIONS. 2018. 9.
22. Xiang, Yangfei*; Tanaka, Yoshiaki*; Patterson, Benjamin; Kang, Young-Jin; Govindaiah, Gubbi; Roselaar, Naomi; Cakir, Bilal; Kim, Kun-Yong; Lombroso, Adam P.; Hwang, Sung-Min; Zhong, Mei; Stanley, Edouard G.; Elefanty, Andrew G.; Naegele, Janice R.; Lee, Sang-Hun; Weissman, Sherman M.; Park, In-Hyun.Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration.CELL STEM CELL. 2017. 21(3):383.
23. Xiang, Yangfei*; Kim, Kun-Yong; Gelernter, Joel; Park, In-Hyun; Zhang, Huiping.Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons.PLOS ONE. 2015. 10(8).
24. Tanaka, Yoshiaki*; Hysolli, Eriona; Su, Juan; Xiang, Yangfei; Kim, Kun-Yong; Zhong, Mei; Li, Yumei; Heydari, Kartoosh; Euskirchen, Ghia; Snyder, Michael P.; Pan, Xinghua; Weissman, Sherman Morton; Park, In-Hyun.Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.STEM CELL REPORTS. 2015. 4(6):1125-1139.